NAD+
Longevity coenzyme
Research overview
A dinucleotide essential to cellular energy metabolism, heavily studied in longevity protocols.
Descriptions reference published research areas for laboratory context only and are not claims of efficacy, safety, or intended use in humans or animals.
- Price
- $210 CAD
- Purity
- ≥99.5% (HPLC)
- Presentation
- 500 mg lyophilized vial
Order / inquire about NAD+
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For laboratory research use only — not for human or veterinary use
NAD+ is a chemical reference material sold strictly for in-vitro laboratory research by qualified professionals. It is not a drug, food, cosmetic, or natural health product; it has not been evaluated or approved by Health Canada; and it must never be ingested, injected, or applied to humans or animals. Sold in Canada only, to purchasers 18+. See our Research Use Policy.
Research encyclopedia
Everything the literature has studied.
For laboratory research use only — not for human or veterinary use. The content below summarizes published research context only. It is not medical advice, makes no therapeutic claims, and describes no intended use in humans or animals. These materials have not been evaluated or approved by Health Canada.
What it is
NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a central pyridine-dinucleotide coenzyme present in all living cells—NOT a peptide. It is essential to cellular energy metabolism and serves as a substrate for the sirtuins and PARPs. Its tissue decline with age has driven research interest in NAD+ itself and its precursors (NMN, NR).
Mechanism of action
Primary electron carrier (NAD+/NADH couple) in glycolysis, the citric-acid cycle, β-oxidation, and the mitochondrial respiratory chain. Beyond redox, NAD+ is a consumed substrate for the sirtuins (SIRT1-7, deacylases) and PARPs (DNA-repair enzymes), and for cyclic ADP-ribose synthases (CD38), thereby linking cellular energy status to gene expression, DNA repair, and metabolic signaling.
Research areas
- Aging and age-related metabolic decline
- Mitochondrial biogenesis and function
- Glucose metabolism and insulin sensitivity
- Cognitive function, DNA repair, and muscle recovery
Studied effects in research models
- Increased blood NAD+ levels after oral NMN/NR supplementation
- Improved skeletal-muscle mitochondrial biogenesis (preclinical/exploratory)
- Sirtuin and PARP pathway activation in cellular models
Effects listed describe observations reported in laboratory or animal research models only — not outcomes claimed for humans or animals.
Biomarkers tracked in related research
Discovery & background
Discovered by Arthur Harden and William Young in 1906 as a heat-stable 'coferment' in yeast fermentation. Its redox role was characterized through the 20th century by Otto Warburg, Hans von Euler-Chelpin, and others. The 21st-century identification of sirtuins and PARPs as NAD+-consuming enzymes, plus the observation of age-related NAD+ decline, renewed interest in NAD+ biology and its precursors.
Considerations & limitations
Research-use-only reference material; not a peptide but a coenzyme. Not approved by Health Canada or the FDA for the uses described. Rapid IV infusions in research settings can cause flushing, nausea, chest tightness, and malaise; caution is warranted in cardiovascular disease. Safety in pregnancy and cancer is not well defined (NAD+ also fuels PARP/repair pathways). Clinical benefits of supplementation/infusion in humans remain modest or inconsistent in controlled trials.
References
- [1]Rajman, Chwalek & Sinclair, 2018 (NAD+ precursor review) — Cell Metab; 27:529-547; PMID: 29514064
- [2]Martens et al., 2018 (NR in healthy adults) — Nat Commun; 9:1286; PMID: 29599478
- [3]Yoshino et al., 2021 (NMN, insulin sensitivity) — Science; 372:1224-1229; PMID: 33888596